p53gene

p53isatranscriptionalactivator,regulatingtheexpressionofMdm2(foritsownregulation)andthegenesinvolvedingrowtharrest,DNArepairandapoptosis ...,Thep53proteinwasboundtothemajoroncogenicproteinofSV40,stronglysuggestingthatitwasadownstreameffectorofthelargeT-antigenpathway.This ...,,TheTP53geneisthemostfrequentlymutatedgene(>50%)inhumancancer,indicatingthattheTP53geneplaysacrucialroleinpreventing...

參考資訊如下
Primary information of p53 gene

p53 is a transcriptional activator, regulating the expression of Mdm2 (for its own regulation) and the genes involved in growth arrest, DNA repair and apoptosis ...

p53

The p53 protein was bound to the major oncogenic protein of SV40, strongly suggesting that it was a downstream effector of the large T-antigen pathway. This ...

The p53 tumor suppressor protein - Genes and Disease

p53

The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation.

說明

TP53 gene

2020年2月1日 — The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which ...

7157

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds ...

TP53 Gene

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds ...

p53 signaling in cancer progression and therapy

由 HE Marei 著作 · 2021 · 被引用 161 次 — The TP53 gene is mutated in approximately half of all human malignancies, including those of the breast, colon, lung, liver, prostate, bladder, ...

p53: Guardian of the Genome

P53 - an overview

p53 is a tumor-suppressor gene that maintains the human genetic stability and the DNA repair capability and is one of the most studied molecules in cancer ...